Four years after the deaths of Damon Macready and Frank D’Amico, Dave Lizewski, bored after having retired from fighting crime as Kick-Ass, begins training with Mindy Macready to become a real hero. Dave’s girlfriend Katie Deauxma breaks off their relationship due to her mistakenly believing Dave to have been cheating on her with Mindy. Following the death of his father, Chris D’Amico accidentally kills his own mother by kicking her tanning bed, causing it to short-circuit. Now in control of his father’s criminal empire, Chris decides to become a supervillain named “The Motherfucker”, adapting a BDSM suit for his costume, and assembles a gang of supervillains called the Toxic Mega Cunts with his aide Javier, swearing vengeance on Kick-Ass.