Neville’s daily routine include experimenting on infected rats to find a cure for the virus, searching for food and supplies in the city, and waiting each day for survivors who might respond to his continuous recorded radio broadcasts, instructing them to meet him at the South Street Seaport by noon. Neville’s only companion is his German Shepherd, Sam. To cope with his loneliness, he regularly “talks” to mannequins he positions at video stores. At night, he barricades himself with Sam inside his home to hide from the Darkseekers. Neville is haunted by memories of his wife Zoe, and daughter Marley, who both died in a helicopter accident during the chaotic evacuation of Manhattan under quarantine.